Background: Manilkara hexandra (Roxb.) dubard is an evergreen tree species that belongs to the Sapotaceae family which has been used in traditional system of medicines since ages in South Asia, especially in Western and Central India. Objective: This review aims to include a thorough report on phytochemicals found in the various sections of the plant, which are responsible for their medicinal properties in turn. Method: All the informations in this article were collated from selected research papers from online database such as PubMed, Web of Science and Scopus. Results: An audit of its literature shows extracts from this plant and bio transformed products possess different activities such as antibacterial, anti-inflammatory, antiulcer, aphrodisiac, immuno-stimulation activity, arthritic activity, and free radical scavenging activity. Apart from therapeutic indications, the products obtained such as edible and nutritious fruit, valuable wood, latex, and bark, are cost effective and are a source of living for local people. The varieties of chemical compounds have been isolated from this species, including sterols, sugar, terpenoids, anthraquinone glycoside, cardiac glycoside, saponin and tannins, etc. Worldwide the large occurrence of this underutilized species offers an incentive to use this plant at crucial levels in the treatment of various ailments. Conclusion: This review attempts to systematically collate the scattered knowledge on M. hexandra, for its botanical elements, phytochemistry, ethnopharmacology, and biological activities, to assess the range of variation among natural populations in opening research areas, and to identify elite cultivars for popularization among farmers/tribal for conservation and sustainable use on conducting field improvement studies.