中西医结合治疗方案对COVID-19的治疗效果:单臂临床试验
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浙江中医药大学 杭州 310053, 浙江中医药大学附属杭州西溪医院 杭州 310014

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Treatment Effects of Integrated TCM and Western Medicine Treatment Scheme on COVID-19: A Single-armed Clinical Trial
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Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China,Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310014, Zhejiang, China

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    摘要:

    背景:新型冠状病毒肺炎自2019年被发现以来,已在200个国家传播,给人类健康带来了前所未有的威胁。目前亟需安全有效的治疗方案。目的:评价中西医结合治疗方案对新型冠状病毒肺炎的治疗效果。方法:在浙江中医药大学附属杭州西溪医院开展单臂临床试验,从725例疑似病例中筛选出102例确诊病例,最终93患者纳入临床实验,采用中西医结合治疗方案进行治疗。结果:93例患者中,最终治愈83例,恶化5例,脱落5例,无死亡病例。根据患者临床资料分析发现,发热、咳嗽、腹泻、乏力的平均缓解时间分别为(4.78±4.61)天、(7.22±4.99)天、(5.28±3.39)天和(5.28±3.39)天。新冠病毒转阴时间为(14.84±5.50)天。多变量cox回归分析显示,年龄、BMI、PISCT、BPC、AST、CK、BS、UPRO是新型冠状病毒肺炎治疗的独立危险因素。结论:本研究提示中西医结合治疗方案能有效治疗新型冠状病毒肺炎。

    Abstract:

    Backgroud: The outbreak of COVID-19 has brought unprecedented perils to human health and raised public health concerns in more than two hundred countries. Safe and effective treatment scheme is needed urgently. Objective: To evaluate the effects of integratedTCM and western medicine treatment scheme on COVID-19. Methods: A single-armed clinical trial was carried out in Hangzhou Xixi Hospital, an affiliated hospital with Zhejiang Chinese Medical University. 102 confirmed cases were screened out from 725 suspected cases and 93 of them were treated with integrated TCM and western medicine treatment scheme. Results: 83 cases were cured, 5 cases deteriorated, and 5 cases withdrew from the study. No deaths were reported. The mean relief time of fever, cough, diarrhea, and fatigue were (4.78 ± 4.61) days, (7.22 ± 4.99) days, (5.28 ± 3.39) days, and (5.28 ± 3.39) days, respectively. It took (14.84 ± 5.50) days for SARS-CoV-2 by nucleic acid amplification-based testing to turn negative. Multivariable cox regression analysis revealed that age, BMI, PISCT, BPC, AST, CK, BS, and UPRO were independent risk factors for COVID-19 treatment. Conclusion: Our study suggested that integrated TCM and western medicine treatment scheme was effective for COVID-19.

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  • 在线发布日期: 2022-03-18
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