榄仁树中富含多酚的组分预防醋酸铅诱导的大鼠慢性氧化应激和心肾毒性
DOI:
作者:
作者单位:

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine,University of Ibadan, Ibadan 200284, Oyo State, Nigeria

作者简介:

通讯作者:

中图分类号:

基金项目:


Polyphenol-rich Fraction of Terminalia catappa Prevents Chronic Lead Acetate Induced Oxidative Stress and Cardiorenal Toxicities in Rats
Author:
Affiliation:

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine,University of Ibadan, Ibadan 200284, Oyo State, Nigeria

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    背景:铅(Pb)是一种自然界中的环境污染物,与心血管和肾脏系统的多种病理有关。目的:本研究旨在评价榄仁树中的富含多酚的组分(PRFTC)对慢性醋酸铅诱导的大鼠心血管和肾脏毒性的调节作用。方法:选取36只大鼠随机分为6组,每组6只。B-F组在饮用水中添加每升100 mg的铅12周诱导铅中毒模型。随后,A组(正常对照组)和B组(模型对照组)不做处理;C组和D组按大鼠体重,分别给予100、200 mg/kg b.w.的PRFTC,E组和F组按大鼠体重,分别给予50 mg/kg b.w.的维生素E和10 mg/kg b.w.的赖诺普利。结果:大鼠暴露于铅后,主要血流动力学参数显著升高 (P < 0.05),发生严重的弥散性血管充血和心脏、肾脏组织出血,炎症和心肌梗死的氧化应激标志物显著升高 (P < 0.05),但血清一氧化氮和全身抗氧化标志物显著降低。此外,铅暴露大鼠的肾和心脏组织中凋亡蛋白Caspase-3表达阳性。PRFTC治疗可减轻大鼠心血管和肾脏系统中的铅毒性反应。结论:结果表明,榄仁树中富含多酚的组分可缓解长期暴露于醋酸铅下的大鼠氧化应激介导的生理内稳态紊乱,并减少由此引发的心血管和肾脏系统的细胞凋亡。因此,榄仁树中富含多酚的组分可作为一种应用于慢性铅中毒的补充剂,具有治疗潜力。

    Abstract:

    Background:Lead (Pb), a naturally occurring environmental contaminant, has been implicated in several pathological conditions of the cardiovascular and renal systems.Objective:The study was designed to evaluate the modulatory roles of the polyphenol-rich fraction of Terminalia catappa on chronic lead acetate-induced cardiovascular and renal toxicities in rats.Methods:Thirty-six rats were randomly selected and divided into six groups of six rats each. Pb toxicity was induced by the administration of 100 mg/L Pb in drinking water for 12 weeks in groups B-F. Groups A and B were left untreated; groups C and D were treated with polyphenol-rich fraction of Terminalia catappa [PRFTC (100 and 200 mg/kg b.w.)]; vitamin E (50 mg/kg b.w.) and lisinopril (10 mg/kg b.w.) were administered to groups E and F, respectively.Results:Exposure of rats to Pb induced significantly elevated (P < 0.05) primary haemodynamic parameters, severe disseminated congestion of blood vessels and haemorrhages in the cardiac and renal tissues, significantly elevated (P < 0.05) markers of oxidative stress markers of inflammation and myocardial infarction, but significantly decreased serum nitric oxide and the systemic antioxidants. Furthermore, rats exposed to Pb showed heightened immune-positive reactions to Caspase-3, a marker of apoptosis, in both renal and cardiac tissues. All manifestations of Pb-associated toxicities in the cardiovascular and renal systems were alleviated by the PRFTC treatment in rats.Conclusion:The polyphenol-rich fraction of T. catappa proved effective in the reduction of oxidative stress-mediated derangements of the physiological homeostasis and decreased apoptosis in the cardiovascular and renal systems of rats chronically exposed to lead acetate toxicities and may therefore have therapeutic potential as a supplement that can be applied in chronic lead poisoning.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2022-06-08
  • 出版日期: